The problems investigated derived from previous studies by C.S Thornton which demonstrated (a) that limb regeneration in the larval salamander Amblystoma opacum is dependent on an extensive but temporary innervation of the epidermis covering the limb tips; the intraepidermal nerves stimulate the epidermis of the limb tip to form a thickened cap of cells which apparently is essential to the inaugration of regeneration and (b) that injured, denervated limbs undergo excessive and extensive regression. Project Number 68.
"Influence of Nerves on the Regeneration and Regression of Limbs in Amphibia,"
Jackson Hole Research Station Annual Report: Vol. 1954
, Article 12.
Available at: http://repository.uwyo.edu/jhrs_reports/vol1954/iss1/12