Date of Award
Dr. Teresa Lehmann
I became involved with the following research on bleomycin analogs and DNA hairpins, after responding on a whim to a campus-wide email regarding a research position in the chemistry department. It has been roughly four years since I was hired by Dr. Teresa Lehmann to begin work on the project, in which time we have published three papers. As an undergraduate researcher I came to be involved in all aspects of the scientific process. For the research that is to be discussed herein, I was involved in the experimental design, sample preparation and data collection, as well as the analysis of complex two-dimensional NMR spectra. I also participated in the writing of the three papers and the presentation of our research at various seminar talks. Throughout my time as an undergraduate researcher, I witnessed the ways in which scientific endeavors can make a positive difference in society. This project specifically elucidates a complicated DNA:Drug interaction which had been previously under controversy due to inconsistencies within the field regarding experimental design. Ultimately, we produced results that could be used to guide the development of a more effective, and less toxic anticancer drug.
The following is to be a summary of the research I conducted while in the Lehmann group, including a reflection on how my involvement in this project has contributed to my identity at the University of Wyoming and beyond.
Murray, Sally A., "A Study on the Structural Relationship between Bleomycin Analogs and DNA Hairpins" (2017). Honors Theses AY 17/18. 1.